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Research Publications
Below please find a listing of publications on Aeris Therapeutics’ first generation lung volume reduction system, the Biologic Lung Volume Reduction (BLVR) System. The design and clinical implementation of Aeris’ second generation system and lead commercial product, the AeriSealTM System, are based, in part, upon the success of BLVR reported in these publications. We anticipate the publication of the initial clinical results with the AeriSeal System in 2010.
Biologic Lung Volume Reduction (BioLVR) Therapy for Advanced Homogeneous Emphysema.
Refaely Y, Dransfield M, Kramer MR, Gotfried M, Leeds W, McLennan G, Tewari S, Krasna M, Criner GJ.
European Respiratory Journal, 2009.
View Abstract
Biologic Lung Volume Reduction (BioLVR) in Advanced Upper Lobe Emphysema: Phase 2 Results.
Criner GJ, Pinto-Plata V, Strange C, Dransfield M, Gotfried M, Leeds W, McLennan G, Refaely Y, Tewari S, Krasna M, Celli B.
American Journal of Respiratory and Critical Care Medicine, 2009.
View Abstract
Biological Lung Volume Reduction: A New Bronchoscopic Therapy for Emphysema.
Reilly J, Washko G, Pinto-Plata V, Velez E, Kenney L, Berger R, Celli B.
Chest, 2007.
View Abstract
Bronchoscopic Lung Volume Reduction in a Sheep Model of Heterogeneous Emphysema.
Tsai L, Hoffman A, Berger R, Ingenito E.
Journal of Bronchology, 2004.
Bronchoscopic Lung Volume Reduction Using Tissue Engineering Principles.
Ingenito E, Berger R, Henderson A, Reilly J, Tsai L, Hoffman A.
American Journal of Respiratory and Critical Care Medicine, 2003.
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Surfactant Therapy in Emphysema: Slowing Disease Progression & Promoting "Medical Lung Volume Reduction."
Ingenito E, Tsai L
American Journal of Respiratory and Critical Care Medicine, 2003.
Physiological Characterization of Variability in Response to Lung Volume Reduction Surgery.
Ingenito E, Loring S, Moy M, Mentzer S, Swanson S, Reilly J,
Journal of Applied Physiology, 2003.
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Bronchoscopic Volume Reduction: a Safe and Effective Alternative to Surgical Therapy for Emphysema.
Ingenito E, Reilly J, Mentzer S, Swanson S, Vin R, Keuhn H, Berger R, Hoffman A.
American Journal of Respiratory and Critical Care Medicine, 2001.
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Interpreting Improvement in Expiratory Flows after Lung Volume Reduction Surgery in Terms of Flow Limitation Theory.
Ingenito E, Loring S, Moy M, Mentzer S, Swanson S, Reilly J.
American Journal of Respiratory and Critical Care Medicine, 2001.
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Limitations of Randomized Clinical Trials for Evaluating Emerging Operations: The Case of Lung Volume Reduction Surgery.
Berger R, Celli B, Meneghetti A, Bagley P, Wright C, Ingenito E, Gray A, Snider G.
Annals of Thoracic Surgery, 2001.
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Comparison of Physiological and Radiological Screening for Lung Volume Reduction Surgery.
Ingenito E, Loring S, Moy M, Mentzer S, Swanson S, Hunsaker A, McKee C, Reilly J.
American Journal of Respiratory and Critical Care Medicine, 2001.
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Preoperative Screening for Lung Volume Reduction Surgery: Usefulness of Combining Thin-Section CT with Physiologic Assessment.
Hunsaker A, Ingenito E, Topal U, Pugatch R, Reilly J.
American Journal of Roentgenology, 1998.
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Relation Between Preoperative Inspiratory Lung Resistance and the Outcome of Lung-Volume-Reduction Surgery for Emphysema.
Ingenito E, Evans R, Loring S, Kaczka D, Rodenhouse J, Body S, Sugarbaker D, Mentzer S, DeCamp M, Reilly J.
New England Journal of Medicine, 1998.
View Abstract
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